Research

We develop quantitative imaging technologies to understand how gene regulation is organized across scales, from molecular interactions and three-dimensional genome architecture to cell states and intact tissues. Our work spans single-molecule dynamics, genome organization, and multiplexed tissue imaging, allowing us to connect regulatory interactions with chromatin architecture, cellular states, and tissue organization. We build new microscopes, molecular probes, automated experimental systems, and computational tools when existing methods cannot resolve the biological questions in front of us. By combining precise measurement with high-throughput perturbation, we aim to build generalizable frameworks that enable scientists to move from observation toward a causal and predictive understanding of gene regulation, cell state, and tissue function across development, aging, and disease.